翻訳と辞書 Words near each other ・ Discovery and development of cephalosporins ・ Discovery and development of cyclooxygenase 2 inhibitors ・ Discovery and development of direct thrombin inhibitors ・ Discovery and development of gliflozins ・ Discovery and development of HIV-protease inhibitors ・ Discovery and development of integrase inhibitors ・ Discovery and development of matrix metalloproteinase inhibitors ・ Discovery and development of memantine and related compounds ・ Discovery and development of neuraminidase inhibitors ・ Discovery and development of non-nucleoside reverse-transcriptase inhibitors ・ Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors ・ Discovery and development of phosphodiesterase 5 inhibitors ・ Discovery and development of proton pump inhibitors ・ Discovery and development of statins ・ Discovery and development of steroidal aromatase inhibitors ・ Discovery and development of triptans ・ Discovery and development of TRPV1 antagonists ・ Discovery and development of tubulin inhibitors ・ Discovery and exploration of the Solar System ・ Discovery and Launch ・ Discovery Arcade (Disneyland Paris) ・ Discovery Atlas ・ Discovery Aviation Model 201 ・ Discovery Bay ・ Discovery Bay (Antarctica) ・ Discovery Bay (Australia) ・ Discovery Bay (disambiguation) ・ Discovery Bay Coastal Park ・ Discovery Bay Ferry Pier ・ Discovery Bay International School Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Discovery and development of triptans ： ウィキペディア英語版 Discovery and development of triptans Triptans is a word commonly used for a class of anti-migraine drugs that are selective 5-hydroxytryptamine/serotonin1B/1D (5-HT1B/1D) agonists. Migraine is a complex disease which affects about 15% of the population and can be highly disabling. Triptans have advantages over ergotamine and dihydroergotamine, such as selective pharmacology, well established safety record and evidence-based prescribing instructions. Triptans are therefore often preferred treatment in migraine.〔 ==History== Search for a new anti-migraine drug started at Glaxo in 1972. Studies in the 1960s showed that vasoconstriction from 5-HT, ergotamine and noradrenaline could reduce migraine attacks. Research also showed that platelet 5-HT level is reduced during migraine. Because there are too many side-effects for 5-HT to be used as a drug, scientists started research on the receptors of 5-HT in order to discover and develop a more specific agonist for 5-HT receptors. Research on the 5-HT receptors and their effect led to discovery of several types and subtypes of 5-HT. AH24167 showed a vasodilation effect instead of vasoconstriction due to the agonist effect on another type of 5-HT receptors later assigned the name 5-HT7. AH25086 was the second compound developed and showed a vasoconstriction effect but was not released as a drug due to low per oral bioavailability. Continued research led to the discovery of the first triptan drug, sumatriptan, that had both vasoconstriction effect, as well as better oral bioavailability. Sumatriptan was first launched in the Netherlands in 1991 and became available in the USA during 1993. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Discovery and development of triptans」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.